[CAS NO. 19970-45-7] SJ572403
PRODUCTS SPECIFICATIONS [19970-45-7]
DESCRIPTION [19970-45-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 275.31 |
| Molecular Formula | C13H17N5O2 |
| SMILES | O=C(N(C1=C(C2=O)N3C(N(C(C)=C3C)CC)=N1)C)N2C |
2 Publications Citing Use of MCE
Summary
SJ572403 (SJ403) is a p27 Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a K d value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs) [1] .
IC50 & Target
Kd: 2.2 mM (p27-KID) [1]
In Vitro
SJ572403 (SJ403) (3 mM) shows specific interactions with specific regions within the D2 subdomain of p27-KID with a K
d
value of 2.2 mM
[1]
.
SJ572403 (0-3 mM) modulates p27's Cdk regulatory
[1]
.
SJ572403 (10 μM-3 mM) displaces p27-D2 from Cdk2/cyclin A and partially restores Cdk2 kinase activity
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 13.89 mg/mL ( 50.45 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6323 mL | 18.1613 mL | 36.3227 mL |
| 5 mM | 0.7265 mL | 3.6323 mL | 7.2645 mL |
| 10 mM | 0.3632 mL | 1.8161 mL | 3.6323 mL |
References
- [1] Iconaru LI, et al. Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1). Sci Rep. 2015 Oct 28;5:15686.
- [2] Pablo Herrera-Nieto, et al. Small Molecule Modulation of Intrinsically Disordered Proteins Using Molecular Dynamics Simulations. J Chem Inf Model. 2020 Oct 26;60(10):5003-5010.
