[CAS NO. 2010159-47-2] MZP-54
PRODUCTS SPECIFICATIONS [2010159-47-2]
DESCRIPTION [2010159-47-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1036.67 |
| Molecular Formula | C55H66ClN7O9S |
| SMILES | O=C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O)C(C=C4)=CC=C4C5=CC6=C(C=C5)N(C(C)=O)[C@@H](C)C[C@H]6NC7=CC=C(Cl)C=C7 |
Summary
IC50 & Target
|
VHL
|
BRD4 BD2 4 nM (Kd) |
In Vitro
MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a K d of 4 nM for Brd4 BD2 . MZP-54 binds to VHL-EloC-EloB protein (VCB) with a K d of 105 ± 24 nM. MZP-54 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC 50 s of 7.08 ± 0.05 and 6.37 ± 0.03, respectively. MZP-54 also exhibits high depletion of cMyc levels [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
Ethanol : 50 mg/mL ( 48.23 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.9646 mL | 4.8231 mL | 9.6463 mL |
| 5 mM | 0.1929 mL | 0.9646 mL | 1.9293 mL |
| 10 mM | 0.0965 mL | 0.4823 mL | 0.9646 mL |
