[CAS NO. 2010159-60-9]  (S,R,S)-AHPC-PEG2-NH2

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PRODUCTS SPECIFICATIONS [2010159-60-9]

Distributor
Catalog
AS945968
Brand
Arctom Scientific
CAS
2010159-60-9

DESCRIPTION [2010159-60-9]

Overview

MDLMFCD31728145
Molecular Weight575.72
Molecular FormulaC28H41N5O6S
SMILESO=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2

For research use only. We do not sell to patients.

Summary

(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs [1] .


IC50 & Target

VHL


In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month