[CAS NO. 20175-84-2] Isodiospyrin

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PRODUCTS SPECIFICATIONS [20175-84-2]

Catalog

AS311176

Brand

Arctom Scientific

CAS

20175-84-2

DESCRIPTION [20175-84-2]

Overview

MDL	MFCD20260856
Molecular Weight	374.34
Molecular Formula	C22H14O6
SMILES	O=C1C=CC(C2=C(C(C3=C4C(C=CC(C4=C(C=C3C)O)=O)=O)=C(C)C=C12)O)=O

For research use only. We do not sell to patients.

Summary

Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I ( Topoisomerase ) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities ^[1] ^[2] ^[3] .

IC50 & Target

Topoisomerase I

In Vitro

Isodiospyrin (10-40 μM) does not induce human topoisomerase I (htopo I)-DNA covalent complexes. However, Isodiospyrin antagonizes Camptothecin-induced, htopo I-mediated DNA cleavage. Isodiospyrin binds htopo I but not DNA. Isodiospyrin exhibits strong inhibitory effect on the kinase activity of htopo I toward splicing factor 2/alternate splicing factor in the absence of DNA ^[1] .
Isodiospyrin against Gram-positive bacteria with MICs ranged from 0.78 to 50 μg/mL. While Isodiospyrin against Pseudomonas aeruginosa ATCC 15443 and S. typhi ranged from 50 to 100 μg/mL. The MIC for M. chelonae is between 6.25 and 25 μg/mL ^[2] .
Isodiospyrin (30 μM; 120-144 hours) shows 81.4 % growth inhibition of P. obscurans . The antifungal activity of Isodiospyrin at 30 μM against P. viticola is 57.7 % ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

Synonyms

[1,2′-Binaphthalene]-5,5′,8,8′-tetrone, 1′,4-dihydroxy-2,3′-dimethyl-, (1R)-

[1,2′-Binaphthalene]-5,5′,8,8′-tetrone, 1′,4-dihydroxy-2,3′-dimethyl-, (R)-

(1R)-1′,4-Dihydroxy-2,3′-dimethyl[1,2′-binaphthalene]-5,5′,8,8′-tetrone

Isodiospyrin

(-)-Isodiospyrin