[CAS NO. 2060259-60-9] SRT1720monohydrochloride

Name: SRT1720monohydrochloride
Brand: Arctom Scientific
SKU: AS942154

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PRODUCTS SPECIFICATIONS [2060259-60-9]

Distributor

Catalog

AS942154

Brand

Arctom Scientific

CAS

2060259-60-9

DESCRIPTION [2060259-60-9]

Overview

MDL	MFCD22580413
Molecular Weight	506.02
Molecular Formula	C25H24ClN7OS
SMILES	O=C(C1=NC2=CC=CC=C2N=C1)NC3=C(C=CC=C3)C4=CN5C(CN6CCNCC6)=CSC5=N4.Cl

For research use only. We do not sell to patients.

23 Publications Citing Use of MCE

Summary

SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC ₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 ^[1] .

IC50 & Target

SIRT1

0.10 μM (EC ₅₀ )

SIRT1

0.16 μM (EC1.5)

SIRT2

37 μM (EC1.5)

In Vitro

SRT 1720 effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, and this is attributed to inhibition of histone acetyltransferase p300 ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SRT 1720 (10, 30, 100 mg/kg, p.o.) treatment significantly reduces fasting blood glucose to near normal levels in Lep ^ob/ob mice ^[1] .
SRT 1720 has ability to protect against the negative effects of diet-induced obesity in mice, and has a connection to metabolic adaptation in fatty acid and oxidative metabolism through downstream targets of SIRT1 such as PGC1α and FOXO1 ^[2] .
SRT 1720 (50-100 mg/kg, p.o.), during emphysema development attenuates elastase-induced airspace enlargement and lung function impairment as well as reduces arterial oxygen saturation in WT mice ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL ( 123.51 mM ; Need ultrasonic)

H ₂ O : 15.7 mg/mL ( 31.03 mM ; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9762 mL	9.8810 mL	19.7621 mL
5 mM	0.3952 mL	1.9762 mL	3.9524 mL
10 mM	0.1976 mL	0.9881 mL	1.9762 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 0.5% HPMC >> 0.2%Tween80

Solubility: 10 mg/mL (19.76 mM); Suspened solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution
4.

Add each solvent one by one: 5% DMSO >> 40% PEG300 >> 5% Tween-80 >> 50% saline

Solubility: ≥ 1 mg/mL (1.98 mM); Clear solution
5.

Add each solvent one by one: 5% DMSO >> 95% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (1.98 mM); Clear solution

* All of the co-solvents are available by MCE.