[CAS NO. 2064175-32-0] FKBP12PROTACdTAG-7
PRODUCTS SPECIFICATIONS [2064175-32-0]
DESCRIPTION [2064175-32-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1210.32 |
| Molecular Formula | C63H79N5O19 |
| SMILES | O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(NCCCOCCOCCOCCCNC(COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)=O)CCC7=CC=C(OC)C(OC)=C7 |
Summary
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12 F36V with expression of FKBP12 F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN [1] .
IC50 & Target
|
FKBP12(F36V) |
BRD4 |
Cereblon |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 150 mg/mL ( 123.93 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.8262 mL | 4.1311 mL | 8.2623 mL |
| 5 mM | 0.1652 mL | 0.8262 mL | 1.6525 mL |
| 10 mM | 0.0826 mL | 0.4131 mL | 0.8262 mL |
