[CAS NO. 2070018-31-2] CARM1-IN-1hydrochloride

Name: CARM1-IN-1hydrochloride
Brand: Arctom Scientific
SKU: AS951125

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PRODUCTS SPECIFICATIONS [2070018-31-2]

Distributor

Catalog

AS951125

Brand

Arctom Scientific

CAS

2070018-31-2

DESCRIPTION [2070018-31-2]

Overview

MDL	-
Molecular Weight	591.72
Molecular Formula	C26H22Br2ClNO3
SMILES	[H]Cl.O=C1/C(CN(CC2=CC=CC=C2)C/C1=C\C3=CC=C(O)C(Br)=C3)=C/C4=CC=C(O)C(Br)=C4

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Sci Bull. 64 (2019) 986-997.

Summary

CARM1-IN-1 hydrochloride is a potent and specific CARM1 (Coactivator-associated arginine methyltransferase 1) inhibitor with IC ₅₀ of 8.6 uM; shows very low activity against PRMT1 and SET7.

IC50 & Target

PRMT4

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 169.00 mM ; Need ultrasonic)

H ₂ O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6900 mL	8.4499 mL	16.8999 mL
5 mM	0.3380 mL	1.6900 mL	3.3800 mL
10 mM	0.1690 mL	0.8450 mL	1.6900 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.22 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (4.22 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2.08 mg/mL (3.52 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.