[CAS NO. 208109-39-1] F13714fumarate
PRODUCTS SPECIFICATIONS [208109-39-1]
DESCRIPTION [208109-39-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 538.97 |
| Molecular Formula | C25H29ClF2N4O5 |
| SMILES | O=C(C1=CC(Cl)=C(F)C=C1)N2CCC(CNCC3=CC=C(C)C(NC)=N3)(F)CC2.OC(/C=C/C(O)=O)=O |
Summary
F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress [1] .
IC50 & Target
|
5-HT 1A Receptor |
In Vitro
F13714 targets 5-HT1A autoreceptors [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels
[1]
.
F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%
[1]
.
F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement
[1]
.
F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in naïve rats
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 250 mg/mL ( 463.85 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8554 mL | 9.2770 mL | 18.5539 mL |
| 5 mM | 0.3711 mL | 1.8554 mL | 3.7108 mL |
| 10 mM | 0.1855 mL | 0.9277 mL | 1.8554 mL |
