[CAS NO. 209342-40-5] Finafloxacin
PRODUCTS SPECIFICATIONS [209342-40-5]
DESCRIPTION [209342-40-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 398.39 |
| Molecular Formula | C20H19FN4O4 |
| SMILES | O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4C[C@]5([H])OCCN[C@@]5([H])C4)=C3C#N)C1=O)O |
Summary
Finafloxacin is a fluoroquinolone antimicrobial agent that exhibits optimum efficacy in slightly acidic environments. Target: Antibacterial Finafloxacin is a pH-activated fluoroquinolone (belonging to a new 8-cyano subclass) to treat serious bacterial infections associated with an acidic environment, including urinary tract infections (UTIs) and Helicobacter pylori infections. Finafloxacin exhibits optimal efficacy in slightly acidic environments (pH 5.0-6.0), under which other fluoroquinolones lose activity. Finafloxacin is highly selective for bacterial type II topoisomerases, including DNA gyrase and DNA topoisomerase IV. [1]
IC50 & Target
|
Quinolone |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01910883 | MerLion Pharmaceuticals GmbH |
Healthy
|
September 2010 | Phase 1 |
| NCT00722735 | MerLion Pharmaceuticals GmbH |
Urinary Tract Infections
|
October 2008 | Phase 2 |
| NCT01904162 | MerLion Pharmaceuticals GmbH |
Pharmacokinetic and Tolerability of Finafloxacin
|
February 2010 | Phase 1 |
| NCT00723502 | MerLion Pharmaceuticals GmbH |
Gram-Negative Bacterial Infections|Helicobacter Infections|Dyspepsia
|
September 2008 | Phase 2 |
| NCT00483158 | MerLion Pharmaceuticals GmbH |
Helicobacter Infections|Urinary Tract Infection
|
August 2007 | Phase 1 |
| NCT01907867 | MerLion Pharmaceuticals GmbH |
Safety and Tolerability
|
January 2012 | Phase 1 |
| NCT01928433 | MerLion Pharmaceuticals GmbH |
Urinary Tract Infections|Acute Pyelonephritis
|
December 2012 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 6.4 mg/mL ( 16.06 mM ; Need ultrasonic and warming)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5101 mL | 12.5505 mL | 25.1010 mL |
| 5 mM | 0.5020 mL | 2.5101 mL | 5.0202 mL |
| 10 mM | 0.2510 mL | 1.2551 mL | 2.5101 mL |
Synonyms
