[CAS NO. 2098836-45-2] BRD4 degrader AT1
PRODUCTS SPECIFICATIONS [2098836-45-2]
DESCRIPTION [2098836-45-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 972.68 |
| Molecular Formula | C48H58ClN9O5S3 |
| SMILES | CC1=C(C)SC2=C1C(C3=CC=C(Cl)C=C3)=N[C@@H](CC(NCCCCCCSC(C)(C)[C@H](NC(C)=O)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)C7=NN=C(C)N27 |
Summary
IC50 & Target
Kd: 44 nM (Brd4 BD2 , cell assay), 38.8 nM (Brd4 BD2 QVK, cell assay), 111 nM (Brd2 BD1 , cell assay), 94 nM (Brd2 BD2 , cell assay), 35 nM (Brd3 BD1 , cell assay), 39 nM (Brd3 BD2 , cell assay), 75 nM (Brd4 BD1 , cell assay), 35 nM (Brd2 BD1 KEA, cell assay) [1]
In Vitro
BRD4 degrader AT1 is a highly selective Brd4 degrader, with a K d of 44 nM, for Brd4 BD2 in cells. BRD4 degrader AT1 also shows K d s of 38.8 nM for a mutant Brd4 BD2 (QVK), 111 ± 14 nM for Brd2 BD1 , 94 ± 9 nM for Brd2 BD2 , 35 ± 3 nM for Brd3 BD1 , 39 ± 8 nM for Brd3 BD2 , 75 ± 23 nM for Brd4 BD1 and 35 ± 4 nM for a Brd2 BD1 mutant (KEA). BRD4 degrader AT1 (1-3 μM) causes remarkable Brd4-selective depletion and has no or little activity against Brd2 and Brd3 [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 102.81 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.0281 mL | 5.1404 mL | 10.2809 mL |
| 5 mM | 0.2056 mL | 1.0281 mL | 2.0562 mL |
| 10 mM | 0.1028 mL | 0.5140 mL | 1.0281 mL |
