[CAS NO. 2101291-07-8] AZD-0284

Name: AZD-0284
Brand: Arctom Scientific
SKU: AS948116

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [2101291-07-8]

Distributor

Catalog

AS948116

Brand

Arctom Scientific

CAS

2101291-07-8

DESCRIPTION [2101291-07-8]

Overview

MDL	-
Molecular Weight	524.43
Molecular Formula	C21H18F6N2O5S
SMILES	O=C([C@@H]1N(C(C)=O)CC2=C1C=CC(S(=O)(C)=O)=C2)NC3=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C3

For research use only. We do not sell to patients.

Summary

AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ . AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment ^[1] .

IC50 & Target

pIC50: 7.4 (FRET RORγ) ^[1]

In Vitro

AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human T _H 17 cells ^[1] .
AZD0284 reduces polarization of T _H 17 into pathogenic T _H 17/1 cells. AZD0284 decreases frequency of single IL-17 ⁺ cell as well as double positive T _H 17/1 cells. AZD0284 reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22 and IL-23R ^[1] ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03029741	AstraZeneca	Plaque Psoriasis Vulgaris	February 21, 2017	Phase 1
NCT03310320	AstraZeneca	Plaque Psoriasis Vulgaris	November 29, 2017	Phase 1
NCT02976831	AstraZeneca\|Parexel	Plaque Psoriasis Vulgaris	December 9, 2016	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 190.68 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9068 mL	9.5342 mL	19.0683 mL
5 mM	0.3814 mL	1.9068 mL	3.8137 mL
10 mM	0.1907 mL	0.9534 mL	1.9068 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.83 mg/mL (1.58 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.83 mg/mL (1.58 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.83 mg/mL (1.58 mM); Clear solution

* All of the co-solvents are available by MCE.