[CAS NO. 2131798-13-3] Ganfeborole hydrochloride
PRODUCTS SPECIFICATIONS [2131798-13-3]
DESCRIPTION [2131798-13-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 293.94 |
| Molecular Formula | C10H14BCl2NO4 |
| SMILES | OB1O[C@H](CN)C2=C(Cl)C=CC(OCCO)=C21.[H]Cl |
2 Publications Citing Use of MCE
Summary
Ganfeborole hydrochloride (GSK656) is a potent antitubercular agent, acting as an inhibitor of Mycobacterium tuberculosis ( Mtb ) leucyl-tRNA synthetase (LeuRS) , with an IC 50 of 0.2 μM.
IC50 & Target
IC50: 0.2 μM ( Mtb LeuRS) [1]
In Vitro
Ganfeborole hydrochloride is highly selective inhibitor for Mycobacterium tuberculosis ( Mtb ) leucyl-tRNA synthetase (LeuRS), with an IC 50 of 0.2 μM, and shows IC 50 s of >300 μM and 132 μM for human mitochondrial LeuRS and human cytoplasmic LeuRS, respectively. Ganfeborole hydrochloride exhibits antitubercular activity with minimal inhibitory concentration (MIC) of 80 nM against Mtb H37Rv. Ganfeborole hydrochloride also exhibits EC 50 s of 381 μM against HepG2 cell, and 137 μM against HepG2 protein synthesis [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Ganfeborole hydrochloride shows potent antitubercular activity in mice infected with M. tuberculosis H37Rv, with ED 99 of 0.4 mg/kg [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 67.5 mg/mL ( 229.64 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.4021 mL | 17.0103 mL | 34.0205 mL |
| 5 mM | 0.6804 mL | 3.4021 mL | 6.8041 mL |
| 10 mM | 0.3402 mL | 1.7010 mL | 3.4021 mL |
