[CAS NO. 2131803-90-0] WYC-209
PRODUCTS SPECIFICATIONS [2131803-90-0]
DESCRIPTION [2131803-90-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 368.45 |
| Molecular Formula | C20H20N2O3S |
| SMILES | O=C(C1=CN=C(C#CC2=CC=C3C(C(C)(C)CCS3=O)=C2)N=C1)OCC |
Summary
IC50 & Target
Retinoic acid receptor [1]
In Vitro
WYC-209 (10 μM; 24 hours) is able to inhibit and block growth of TRCs of human tumor cells in culture with a long-lasting effect [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Apoptosis Analysis [1]
| Cell Line: | A2780, A549, MCF-7, MDA-MB-435s, A375 cells |
| Concentration: | 10 μM |
| Incubation Time: | 24 hours |
| Result: | TRCs failed to resume growth 5 days after the drug washout. |
In Vivo
WYC-209 (0.022-0.22 mg/kg; i.v.; once every two days for 25 days) inhibits tumor metastasis in C57BL/6 mice bearing lung metastases [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Female immune-competent C57BL/6 mice [1] |
| Dosage: | 0.022, 0.22 mg/kg |
| Administration: | Intravenous injection; once every two days for 25 days |
| Result: | Four out of eight mice formed lung metastases at dose of 0.022 mg /kg, only one out of eight mice formed lung metastases at dose of 0.22 mg/kg. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 83.33 mg/mL ( 226.16 mM ; Need ultrasonic)
H 2 O : < 0.1 mg/mL (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7141 mL | 13.5704 mL | 27.1407 mL |
| 5 mM | 0.5428 mL | 2.7141 mL | 5.4281 mL |
| 10 mM | 0.2714 mL | 1.3570 mL | 2.7141 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.65 mM); Clear solution
