[CAS NO. 21392-57-4] 5,7-Dimethoxyflavone

Name: 5,7-Dimethoxyflavone
Brand: Arctom Scientific
SKU: AS026513

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PRODUCTS SPECIFICATIONS [21392-57-4]

Distributor

Catalog

AS026513

Brand

Arctom Scientific

CAS

21392-57-4

DESCRIPTION [21392-57-4]

Overview

MDL	MFCD00016943
Molecular Weight	282.29
Molecular Formula	C17H14O4
SMILES	O=C1C=C(C2=CC=CC=C2)OC3=CC(OC)=CC(OC)=C13

For research use only. We do not sell to patients.

Summary

5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora , has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As . 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor ^[1] ^[2] .

IC50 & Target

CYP3A

Breast Cancer Resistance Protein (BCRP)

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 354.25 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5425 mL	17.7123 mL	35.4246 mL
5 mM	0.7085 mL	3.5425 mL	7.0849 mL
10 mM	0.3542 mL	1.7712 mL	3.5425 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.86 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.86 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.86 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4H-1-Benzopyran-4-one, 5,7-dimethoxy-2-phenyl-

Flavone, 5,7-dimethoxy-

5,7-Dimethoxy-2-phenyl-4H-1-benzopyran-4-one

5,7-Dimethoxyflavone

Chrysin dimethyl ether

5,7-Dimethoxy-4-oxo-2-phenyl-4H-1-benzopyran

5,7-Dimethoxy-2-phenyl-4H-chromen-4-one

5,7-Di-O-methylchrysin

5,7-Di-O-methoxy chrysin