[CAS NO. 2139356-35-5] AMPD2 inhibitor 1

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PRODUCTS SPECIFICATIONS [2139356-35-5]

Catalog

HY-103673

Brand

MCE

CAS

2139356-35-5

DESCRIPTION [2139356-35-5]

Overview

MDL	-
Molecular Weight	382.45
Molecular Formula	C25H22N2O2
SMILES	C[C@H](C1=C2C=CC=CC2=CC=C1)NCC3=CC=C(C4=NC=C(C(O)=O)C=C4)C=C3

For research use only. We do not sell to patients.

Summary

AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 ( AMPD2 ) inhibitor, used in the research of sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions.

IC50 & Target

AMPD2 ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL ( 87.15 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6147 mL	13.0736 mL	26.1472 mL
5 mM	0.5229 mL	2.6147 mL	5.2294 mL
10 mM	0.2615 mL	1.3074 mL	2.6147 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (6.54 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.54 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.25 mg/mL (3.27 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Richard J. Johnson, et al. Targeting amp deaminase 2 for ameliorating craving for sugar and other substances. WO2017180743A1.