[CAS NO. 2140-72-9] 2'-O-Methylcytidine

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PRODUCTS SPECIFICATIONS [2140-72-9]

Catalog

HY-W011834

Brand

MCE

CAS

2140-72-9

DESCRIPTION [2140-72-9]

Overview

MDL	MFCD11519076
Molecular Weight	257.24
Molecular Formula	C10H15N3O5
SMILES	O[C@H]1[C@@H](OC)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1CO

For research use only. We do not sell to patients.

Summary

2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication . 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H ₂ O : 62.5 mg/mL ( 242.96 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8874 mL	19.4371 mL	38.8742 mL
5 mM	0.7775 mL	3.8874 mL	7.7748 mL
10 mM	0.3887 mL	1.9437 mL	3.8874 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 100 mg/mL (388.74 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Steven S Carroll, et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem. 2003 Apr 4;278(14):11979-84

Synonyms

Cytidine, 2′-O-methyl-

2′-O-Methylcytidine

O²′-Methylcytidine