[CAS NO. 2140807-17-4] Pomalidomide-PEG2-COOH

Name: Pomalidomide-PEG2-COOH
Brand: Arctom Scientific
SKU: AS947470

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PRODUCTS SPECIFICATIONS [2140807-17-4]

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Catalog

AS947470

Brand

Arctom Scientific

CAS

2140807-17-4

DESCRIPTION [2140807-17-4]

Overview

MDL	-
Molecular Weight	433.41
Molecular Formula	C20H23N3O8
SMILES	O=C(O)CCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

For research use only. We do not sell to patients.

Summary

Pomalidomide-PEG2-COOH (Pomalidomide 4'-PEG2-acid) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology ^[1] .

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 288.41 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3073 mL	11.5364 mL	23.0728 mL
5 mM	0.4615 mL	2.3073 mL	4.6146 mL
10 mM	0.2307 mL	1.1536 mL	2.3073 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.80 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.80 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Fangqing Zhang, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.