[CAS NO. 2148339-28-8] AS2717638
PRODUCTS SPECIFICATIONS [2148339-28-8]
DESCRIPTION [2148339-28-8]
Overview
| MDL | MFCD31813748 |
|---|---|
| Molecular Weight | 447.48 |
| Molecular Formula | C25H25N3O5 |
| SMILES | O=C1N(C2=NOC3=C2C=C(C)C=C3)C=C(C(N4CCCCC4)=O)C5=C1C=C(OC)C(OC)=C5 |
Summary
AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC 50 of 38 nM for hLPA5. AS2717638 also significantly improves PGE 2 -, PGF 2α -, and AMPA-induced allodynia [1] .
IC50 & Target
IC50: 38 nM (hLPA5) [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 60 mg/mL ( 134.08 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2347 mL | 11.1737 mL | 22.3474 mL |
| 5 mM | 0.4469 mL | 2.2347 mL | 4.4695 mL |
| 10 mM | 0.2235 mL | 1.1174 mL | 2.2347 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 6 mg/mL (13.41 mM); Clear solution
