[CAS NO. 21802-37-9] CaerulomycinA

Name: CaerulomycinA
Brand: Arctom Scientific
SKU: AS466196

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PRODUCTS SPECIFICATIONS [21802-37-9]

Distributor

Catalog

AS466196

Brand

Arctom Scientific

CAS

21802-37-9

DESCRIPTION [21802-37-9]

Overview

MDL	MFCD03093715
Molecular Weight	229.23
Molecular Formula	C12H11N3O2
SMILES	COC1=CC(C2=NC=CC=C2)=NC(/C=N/O)=C1.[(E)]

For research use only. We do not sell to patients.

Summary

Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases ^[1] .

IC50 & Target

Antifungal ^[1]
TGF-β-Smad3 ^[1]

Appearance

Solid

Source

Streptomyces caeruleus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 150 mg/mL ( 654.36 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3624 mL	21.8122 mL	43.6243 mL
5 mM	0.8725 mL	4.3624 mL	8.7249 mL
10 mM	0.4362 mL	2.1812 mL	4.3624 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (10.91 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (10.91 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Gurram RK, et al. Caerulomycin A enhances transforming growth factor-β (TGF-β)-Smad3 protein signaling by suppressing interferon-γ (IFN-γ)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs). J Biol Chem. 2014 Jun 20;289(25):17515-28.

Synonyms

[2,2′-Bipyridine]-6-carboxaldehyde, 4-methoxy-, oxime, (E)-

Cerulomycin

(E)-4-Methoxy[2,2′-bipyridine]-6-carboxaldehyde oxime

Caerulomycin A

Caerulomycin