[CAS NO. 2220184-50-7] CDK12-IN-3
PRODUCTS SPECIFICATIONS [2220184-50-7]
DESCRIPTION [2220184-50-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 470.52 |
| Molecular Formula | C23H28F2N8O |
| SMILES | CC(C)N1C2=NC(N3CCCC[C@H]3CCO)=NC(NCC4=NC5=C(C(F)=C(F)C=C5)N4)=C2N=C1 |
Summary
CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC 50 of 491 nM in enzymatic assay.
IC50 & Target
|
CDK12 491 nM (IC 50 ) |
In Vitro
CDK12-IN-3 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 µM. CDK12-IN-3 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 531.33 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1253 mL | 10.6265 mL | 21.2531 mL |
| 5 mM | 0.4251 mL | 2.1253 mL | 4.2506 mL |
| 10 mM | 0.2125 mL | 1.0627 mL | 2.1253 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.33 mg/mL (4.95 mM); Clear solution
