[CAS NO. 2230849-55-3] EHMT2-IN-1

Name: EHMT2-IN-1
Brand: Arctom Scientific
SKU: AS950794

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PRODUCTS SPECIFICATIONS [2230849-55-3]

Distributor

Catalog

AS950794

Brand

Arctom Scientific

CAS

2230849-55-3

DESCRIPTION [2230849-55-3]

Overview

MDL	-
Molecular Weight	353.42
Molecular Formula	C18H23N7O
SMILES	COC1=C(N2N=CC(CNC)=C2)C=C(NC3=NC(NC)=CC(C)=N3)C=C1

For research use only. We do not sell to patients.

Summary

EHMT2-IN-1 is a potent EHMT inhibitor, with IC ₅₀ s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2. Used in the research of blood disorder or cancer ^[1] .

IC50 & Target

EHMTI PEP

<100 nM (IC ₅₀ )

EHMT2 PEP

<100 nM (IC ₅₀ )

EHMT2 ICW

<100 nM (IC ₅₀ )

In Vitro

EHMT2-IN-1 (Compound 108) potent EHMT inhibitor, with IC ₅₀ s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2 ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 55 mg/mL ( 155.62 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8295 mL	14.1475 mL	28.2949 mL
5 mM	0.5659 mL	2.8295 mL	5.6590 mL
10 mM	0.2829 mL	1.4147 mL	2.8295 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.92 mg/mL (2.60 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.92 mg/mL (2.60 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.92 mg/mL (2.60 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] John Emmerson Campbell, et al. Amine-substituted heterocyclic compounds as ehmt2 inhibitors and methods of use thereof. WO2018118842A1