[CAS NO. 2244520-98-5] Homo-PROTAC cereblon degrader 1
PRODUCTS SPECIFICATIONS [2244520-98-5]
DESCRIPTION [2244520-98-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 660.63 |
| Molecular Formula | C32H32N6O10 |
| SMILES | O=C(N1C2CCC(NC2=O)=O)C3=CC=CC(NCCOCCOCCNC4=C5C(C(N(C6CCC(NC6=O)=O)C5=O)=O)=CC=C4)=C3C1=O |
Summary
Homo-PROTAC cereblon degrader 1 (compound 15a) is a highly potent and efficient Cereblon ( CRBN ) degrader with only minimal effects on IKZF1 and IKZF3 [1] .
IC50 & Target
|
Cereblon |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 200 mg/mL ( 302.74 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5137 mL | 7.5685 mL | 15.1371 mL |
| 5 mM | 0.3027 mL | 1.5137 mL | 3.0274 mL |
| 10 mM | 0.1514 mL | 0.7569 mL | 1.5137 mL |
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1.
