[CAS NO. 2255-50-7] Robustine

Name: Robustine
Brand: Arctom Scientific
SKU: AS296854

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PRODUCTS SPECIFICATIONS [2255-50-7]

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Catalog

AS296854

Brand

Arctom Scientific

CAS

2255-50-7

DESCRIPTION [2255-50-7]

Overview

MDL	-
Molecular Weight	215.20
Molecular Formula	C12H9NO3
SMILES	OC1=C2N=C(OC=C3)C3=C(OC)C2=CC=C1

For research use only. We do not sell to patients.

Summary

Robustine, a furoquinoline alkaloid, from Dictamnus albus , exhibits inhibitory potency against human phosphodiesterase 5 ( hPDE5A ) in vitro ^[1] .

IC50 & Target

PDE5A

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 464.68 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6468 mL	23.2342 mL	46.4684 mL
5 mM	0.9294 mL	4.6468 mL	9.2937 mL
10 mM	0.4647 mL	2.3234 mL	4.6468 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (11.62 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.62 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Nam KW, et al. Inhibitory effects of furoquinoline alkaloids from Melicope confusa and Dictamnus albus against human phosphodiesterase 5 (hPDE5A) in vitro. Arch Pharm Res. 2005 Jun;28(6):675-9.

Synonyms

Furo[2,3-b]quinolin-8-ol, 4-methoxy-

4-Methoxyfuro[2,3-b]quinolin-8-ol

Robustine (Haplophyllum)

Robustine

8-Hydroxydictamnine

NPLC 0314