[CAS NO. 2277-28-3] 1-Linoleoyl Glycerol

Name: 1-Linoleoyl Glycerol
Brand: Arctom Scientific
SKU: AS210188

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PRODUCTS SPECIFICATIONS [2277-28-3]

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Catalog

AS210188

Brand

Arctom Scientific

CAS

2277-28-3

DESCRIPTION [2277-28-3]

Overview

MDL	MFCD00270409
Molecular Weight	354.52
Molecular Formula	C21H38O4
SMILES	CCCCC/C=C\C/C=C\CCCCCCCC(OCC(O)CO)=O

For research use only. We do not sell to patients.

Summary

1-Linoleoyl Glycerol is a fatty acid glycerol.

IC50 & Target

The (R)-1-Linoleoyl Glycerol and (S)-1-Linoleoyl Glycerol exhibit Lipoprotein-associated phospholipase A ₂ (Lp-PLA ₂ ) inhibitory activities with IC ₅₀ values of 45.0 and 52.0 μM, respectively ^[1] .

Appearance

Oil

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 282.07 mM )

Ethanol : 100 mg/mL ( 282.07 mM ; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8207 mL	14.1036 mL	28.2072 mL
5 mM	0.5641 mL	2.8207 mL	5.6414 mL
10 mM	0.2821 mL	1.4104 mL	2.8207 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Lee WS, et al. Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3573-5.

Synonyms

9,12-Octadecadienoic acid (9Z,12Z)-, 2,3-dihydroxypropyl ester

Linolein, 1-mono-

9,12-Octadecadienoic acid (Z,Z)-, 2,3-dihydroxypropyl ester

α-Glyceryl linoleate

1-Monolinolein

Glycerol 1-monolinolate

1-Glyceryl linoleate

Oleinate 288

α-Monolinolein

1-Linoleylglycerol

1-Monolinoleoyl-rac-glycerol

(±)-2,3-Dihydroxypropyl 9(Z),12(Z)-octadecadienoate

2,3-Dihydroxypropyl linoleate

3-O-(9Z,12Z-Octadecadienoyl)glycerol

1-O-(9Z,12Z-Octadecadienoyl)glycerol

(9Z,12Z)-2,3-Dihydroxypropyl octadecadienoate

1-Monolinoleoyl-rac-glycerol

1-Linoleoyl-rac-glycerol