[CAS NO. 23052-81-5] L-AP4
PRODUCTS SPECIFICATIONS [23052-81-5]
DESCRIPTION [23052-81-5]
Overview
| MDL | MFCD00083244 |
|---|---|
| Molecular Weight | 183.10 |
| Molecular Formula | C4H10NO5P |
| SMILES | O=C(O)[C@@H](N)CCP(O)(O)=O |
1 Publications Citing Use of MCE
Summary
IC50 & Target
|
mGlu 4 0.13 μM (EC 50 ) |
mGlu8 0.29 μM (EC 50 ) |
mGlu 6 1.0 μM (EC 50 ) |
mGlu7 249 μM (EC 50 ) |
In Vivo
L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction
[2]
.
Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats
[2]
.
Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: |
Rats.
[2]
|
| Dosage: | 5-30 μg. |
| Administration: | Intrathecal inhection 4-5 days. |
| Result: | Dose-dependently increased paw withdrawal threshold. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 50 mg/mL ( 273.07 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.4615 mL | 27.3075 mL | 54.6150 mL |
| 5 mM | 1.0923 mL | 5.4615 mL | 10.9230 mL |
| 10 mM | 0.5461 mL | 2.7307 mL | 5.4615 mL |
References
- [1] Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61(5):1969-1989.
- [2] Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312(1):120-6.
Synonyms
