[CAS NO. 2310135-18-1] N-deacetylatedBMS-202
PRODUCTS SPECIFICATIONS [2310135-18-1]
DESCRIPTION [2310135-18-1]
Overview
| MDL | MFCD31382120 |
|---|---|
| Molecular Weight | 377.48 |
| Molecular Formula | C23H27N3O2 |
| SMILES | NCCNCC1=CC=C(OCC2=C(C)C(C3=CC=CC=C3)=CC=C2)N=C1OC |
Summary
N-deacetylated BMS-202 is the deacetylated of BMS-202. BMS-202 is an inhibitor of the PD-1/PD-L1 interaction, mainly used for cancer treatment.
In Vitro
BMS-202 inhibits PD-1/PD-Ll interaction, and may augment therapeutic immune response to a number of histologically distinct tumors. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many systems [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 36 mg/mL ( 95.37 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6491 mL | 13.2457 mL | 26.4915 mL |
| 5 mM | 0.5298 mL | 2.6491 mL | 5.2983 mL |
| 10 mM | 0.2649 mL | 1.3246 mL | 2.6491 mL |
References
