[CAS NO. 2331259-45-9] Pomalidomide-amino-PEG4-NH2hydrochloride

Name: Pomalidomide-amino-PEG4-NH2hydrochloride
Brand: Arctom Scientific
SKU: AS940389

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PRODUCTS SPECIFICATIONS [2331259-45-9]

Distributor

Catalog

AS940389

Brand

Arctom Scientific

CAS

2331259-45-9

DESCRIPTION [2331259-45-9]

Overview

MDL	-
Molecular Weight	542.97
Molecular Formula	C23H31ClN4O9
SMILES	O=C(COCCOCCOCCOCCN)NC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O.Cl

For research use only. We do not sell to patients.

Summary

Pomalidomide-amino-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology ^[1] .

IC50 & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 460.43 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8417 mL	9.2086 mL	18.4172 mL
5 mM	0.3683 mL	1.8417 mL	3.6834 mL
10 mM	0.1842 mL	0.9209 mL	1.8417 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 6.25 mg/mL (11.51 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 6.25 mg/mL (11.51 mM); Clear solution

* All of the co-solvents are available by MCE.