[CAS NO. 2418-52-2] D-Threitol

Name: D-Threitol
Brand: Arctom Scientific
SKU: AS614845

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PRODUCTS SPECIFICATIONS [2418-52-2]

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Catalog

AS614845

Brand

Arctom Scientific

CAS

2418-52-2

DESCRIPTION [2418-52-2]

Overview

MDL	MFCD00067036
Molecular Weight	122.12
Molecular Formula	C4H10O4
SMILES	OC[C@H]([C@@H](CO)O)O

For research use only. We do not sell to patients.

Summary

D-threitol serves as a antifreeze agent in the Alaskan beetle Upis ceramboides .

IC50 & Target

Human Endogenous Metabolite

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 2047.17 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.1887 mL	40.9433 mL	81.8867 mL
5 mM	1.6377 mL	8.1887 mL	16.3773 mL
10 mM	0.8189 mL	4.0943 mL	8.1887 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (17.03 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (17.03 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (17.03 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Walters KR Jr, et al. Cryoprotectant biosynthesis and the selective accumulation of threitol in the freeze-tolerant Alaskan beetle, Upis ceramboides. J Biol Chem. 2009 Jun 19;284(25):16822-31.

Synonyms

1,2,3,4-Butanetetrol, (2R,3R)-

Threitol, D-

1,2,3,4-Butanetetrol, [R-(R*,R*)]-

(2R,3R)-1,2,3,4-Butanetetrol

D-Threitol