[CAS NO. 245075-84-7] LR-90

Name: LR-90
Brand: Arctom Scientific
SKU: AS412152

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PRODUCTS SPECIFICATIONS [245075-84-7]

Distributor

Catalog

AS412152

Brand

Arctom Scientific

CAS

245075-84-7

DESCRIPTION [245075-84-7]

Overview

MDL	-
Molecular Weight	709.57
Molecular Formula	C35H34Cl2N4O8
SMILES	O=C(NC1=CC=C(C=C1)OC(C)(C)C(O)=O)NC(C(Cl)=C2)=CC=C2CC3=CC=C(C(Cl)=C3)NC(NC4=CC=C(C=C4)OC(C)(C)C(O)=O)=O

For research use only. We do not sell to patients.

Summary

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes ^[1] . LR-90 is also used in the research of diabetic animal model ^[2] .

IC50 & Target

AGE ^[1]

In Vitro

LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours ^[1] .
LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours ^[1] .
LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	THP-1 cells
Concentration:	0, 25, 50, 100, and 200 μM
Incubation Time:	24 hours
Result:	Showed no cytotoxicity to THP-1 cells.

RT-PCR ^[1]

Cell Line:	THP-1 cells
Concentration:	0, 25, 50, 100, and 200 μM
Incubation Time:	One hour before S100b addition for 4 hours
Result:	Dose-dependently inhibited mRNA expression of RAGE, MCP-1, COX-2, IP-10, and NOX2 stimulated with S100b.

In Vivo

LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats ^[2] .
LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ZDF rats (13 to 40 weeks) ^[2]
Dosage:	50 mg/L
Administration:	P.O. for 27 weeks
Result:	Significantly reduced plasma triacylglycerol and cholesterol by ∼55% and ∼30%, respectively. Modestly affected hyperglycaemia and blood pressure. Lowered the body weight.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 140.93 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4093 mL	7.0465 mL	14.0930 mL
5 mM	0.2819 mL	1.4093 mL	2.8186 mL
10 mM	0.1409 mL	0.7047 mL	1.4093 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (3.52 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.52 mM); Clear solution

* All of the co-solvents are available by MCE.