[CAS NO. 257930-74-8] Secoisolariciresinol diglucoside
PRODUCTS SPECIFICATIONS [257930-74-8]
DESCRIPTION [257930-74-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 686.70 |
| Molecular Formula | C32H46O16 |
| SMILES | COC1=C(O)C=CC(C[C@H](CO[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO)[C@](CO[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)([H])CC4=CC(OC)=C(O)C=C4)=C1 |
3 Publications Citing Use of MCE
Summary
In Vitro
Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals
[1]
.
Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Hand feeding mice (10 weeks old, male) are injected with TNFα [2] |
| Dosage: | 4 mg/mouse |
| Administration: | P.o. 2 h before i.c. administration of TNFα |
| Result: | Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : ≥ 100 mg/mL ( 145.62 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.4562 mL | 7.2812 mL | 14.5624 mL |
| 5 mM | 0.2912 mL | 1.4562 mL | 2.9125 mL |
| 10 mM | 0.1456 mL | 0.7281 mL | 1.4562 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (72.81 mM); Clear solution; Need ultrasonic
References
- [1] Mishra OP, et al. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett. 2013 Oct 1;23(19):5325-8.
- [2] Rom S, et, al. Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation. J Neuroinflammation. 2018 Jan 27;15(1):25.
