[CAS NO. 260980-89-0] Topilutamide
PRODUCTS SPECIFICATIONS [260980-89-0]
DESCRIPTION [260980-89-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 403.23 |
| Molecular Formula | C13H11F6N3O5 |
| SMILES | O=C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)C(C)(O)CNC(C(F)(F)F)=O |
Summary
Topilutamide is a topical nonsteroidal antiandrogen (NSAA).
In Vivo
Prostate cancer is the most common cancer and one of the leading causes of cancer deaths in men. One of the commonly used approaches to treat metastatic prostate cancer is via first-generation nonsteroidal anti-androgens (NSAAs), namely Flutamide, Nilutamide, Bicalutamide and Topilutamide [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 150 mg/mL ( 372.00 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4800 mL | 12.3999 mL | 24.7997 mL |
| 5 mM | 0.4960 mL | 2.4800 mL | 4.9599 mL |
| 10 mM | 0.2480 mL | 1.2400 mL | 2.4800 mL |
References
- [1] Suresh PS, et al. Review of HPLC and LC-MS/MS assays for the determination of various nonsteroidal anti-androgens used in the treatment of prostate cancer. Biomed Chromatogr. 2017 Jun 21.
- [2] Sovak M, Seligson AL, Kucerova R, Bienova M, Hajduch M, Bucek M. Fluridil, a rationally designed topical agent for androgenetic alopecia: first clinical experience [published correction appears in Dermatol Surg 2002 Oct;28(8):following 970]. Dermatol Surg. 2002;28(8):678-685.
Synonyms
