[CAS NO. 2642-98-0] 6-Aminochrysene
PRODUCTS SPECIFICATIONS [2642-98-0]
DESCRIPTION [2642-98-0]
Overview
| MDL | MFCD00003699 |
|---|---|
| Molecular Weight | 243.30 |
| Molecular Formula | C18H13N |
| SMILES | NC1=C2C=CC=CC2=C3C(C4=CC=CC=C4C=C3)=C1 |
Summary
6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer .
In Vitro
6-Aminochrysene inhibits the hydroxylation of aniline, 0-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. Pre-treatment of rats with 6-aminochrysene markedly decreases the N-demethylation in vitro but significantly increases the hydroxylation and the 0-demethylation [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
6-Aminochrysene is an inhibitor of the growth of several solid experimental tumours in vivo and has a cancerostatic effect on human breast cancer [1] . Long term topical skin application of 6-Aminochrysene to mice induces development of benign skin tumors after 3 months and of skin malignancies after 7 months. Female mice respond earlier than males. Induction of skin tumors is more rapid when 6-Aminochrysene is applied ventrally instead of dorsally. Urinary excretion is about twice as high after skin application than after oral administration [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 411.02 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.1102 mL | 20.5508 mL | 41.1015 mL |
| 5 mM | 0.8220 mL | 4.1102 mL | 8.2203 mL |
| 10 mM | 0.4110 mL | 2.0551 mL | 4.1102 mL |
-
1.
References
Synonyms
