[CAS NO. 2880-49-1] Heraclenin

Name: Heraclenin
Brand: Arctom Scientific
SKU: AS904287

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [2880-49-1]

Distributor

Catalog

AS904287

Brand

Arctom Scientific

CAS

2880-49-1

DESCRIPTION [2880-49-1]

Overview

MDL	MFCD01725710
Molecular Weight	286.28
Molecular Formula	C16H14O5
SMILES	CC1(C)[C@H](O1)COC2=C(OC=C3)C3=CC(C=C4)=C2OC4=O

For research use only. We do not sell to patients.

Summary

Heraclenin, a natural furanocoumarin, significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT) ^[1] .

IC50 & Target

NFAT ^[1]

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 349.31 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4931 mL	17.4654 mL	34.9308 mL
5 mM	0.6986 mL	3.4931 mL	6.9862 mL
10 mM	0.3493 mL	1.7465 mL	3.4931 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (8.73 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Márquez N, et al. Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT. Planta Med. 2004 Nov;70(11):1016-21.

Synonyms

7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2R)-3,3-dimethyl-2-oxiranyl]methoxy]-

7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-epoxy-3-methylbutoxy)-, (R)-(+)-

7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(3,3-dimethyloxiranyl)methoxy]-, (R)-

Heraclenin

7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2R)-3,3-dimethyloxiranyl]methoxy]-

9-[[(2R)-3,3-Dimethyl-2-oxiranyl]methoxy]-7H-furo[3,2-g][1]benzopyran-7-one

Prangenin

(+)-Heraclenin