[CAS NO. 289715-28-2] CB300919

Name: CB300919
Brand: Arctom Scientific
SKU: AS402452

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PRODUCTS SPECIFICATIONS [289715-28-2]

Distributor

Catalog

AS402452

Brand

Arctom Scientific

CAS

289715-28-2

DESCRIPTION [289715-28-2]

Overview

MDL	-
Molecular Weight	584.11
Molecular Formula	C32H34ClN7O2
SMILES	CN1CCN(CC1)CC2=NC3=C(C(N2C)=O)C=C(CN(CC#C)C4=CC=C(C=C4)C(NCC5=CC=CN=C5)=O)C(Cl)=C3

For research use only. We do not sell to patients.

Summary

CB 300919 is a quinazoline-based antitumour agent with high activity in the CH1 human ovarian tumour xenograft. CB 300919 has a continuous exposure (96 h) growth inhibition IC ₅₀ value of 2 nM in human CH1 ovarian tumor xenograft ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 171.20 mM )

H ₂ O : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7120 mL	8.5600 mL	17.1201 mL
5 mM	0.3424 mL	1.7120 mL	3.4240 mL
10 mM	0.1712 mL	0.8560 mL	1.7120 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 3 mg/mL (5.14 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 3 mg/mL (5.14 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 3 mg/mL (5.14 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702.