[CAS NO. 292057-76-2] IMB-XH1

Name: IMB-XH1
Brand: Arctom Scientific
SKU: AS941677

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PRODUCTS SPECIFICATIONS [292057-76-2]

Distributor

Catalog

AS941677

Brand

Arctom Scientific

CAS

292057-76-2

DESCRIPTION [292057-76-2]

Overview

MDL	MFCD01466199
Molecular Weight	333.41
Molecular Formula	C19H15N3OS
SMILES	OC1=C(N=CC=C2)C2=CC=C1C(NC3=CC=CC=N3)C4=CC=CS4

For research use only. We do not sell to patients.

Summary

IMB-XH1 is an inhibitor of myeloid cell factor 1 ( Mcl-1 ) ^[1] . IMB-XH1 is a non-competitive Delhi metallo-β-lactamase ( NDM-1 ) inhibitor. The IC ₅₀ s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively ^[2] .

IC50 & Target

Mcl-1

In Vitro

IMB-XH1 (Compound 2) is a Mcl-1 inhibitor ^[1] . IMB-XH is screened out with the IC ₅₀ value of 0.4637 μM at the concentration of 20 μg/mL. IMB-XH1 (20 μg/mL) can increase the sensitivity of E. coli BL21 (DE3) (pET-30a(+)-NDM-1) to ampicillinby more than 8 times. IMB-XHI may have a broad spectrum of metallo-β-lactamases (MBLs) inhibitory activity. The combination of IMB-XH1 and Meropenem (MEM) may have potentials to treat infections caused by metallo-β-lactamases-positive, carbapenem-resistant Gram-negative pathogens ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL ( 99.97 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9993 mL	14.9966 mL	29.9931 mL
5 mM	0.5999 mL	2.9993 mL	5.9986 mL
10 mM	0.2999 mL	1.4997 mL	2.9993 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.08 mg/mL (6.24 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution

* All of the co-solvents are available by MCE.