[CAS NO. 2971-90-6] Clopidol
PRODUCTS SPECIFICATIONS [2971-90-6]
DESCRIPTION [2971-90-6]
Overview
| MDL | MFCD22123390 |
|---|---|
| Molecular Weight | 192.04 |
| Molecular Formula | C7H7Cl2NO |
| SMILES | OC1=C(Cl)C(C)=NC(C)=C1Cl |
Summary
IC50 & Target
|
Plasmodium |
Coccidia |
In Vitro
Clopidol is active against Plasmodium falciparum W2 (chloroquine-resistant) and FCR3 (atovaquone-resistant) strains in the low micromolar range [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Clopidol (31.25-93.75 mg/kg feed; p.o. for 10 d) decreases rate of oocyst sporulation of Eimeria tenella [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
0.1 M NaOH : 26 mg/mL ( 135.39 mM ; ultrasonic and adjust pH to 3 with NaOH)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.2072 mL | 26.0362 mL | 52.0725 mL |
| 5 mM | 1.0414 mL | 5.2072 mL | 10.4145 mL |
| 10 mM | 0.5207 mL | 2.6036 mL | 5.2072 mL |
References
- [1] Pang GF, et, al. Determination of clopidol residues in chicken tissues by high-performance liquid chromatography-mass spectrometry. J Chromatogr A. 2000 Jun 16;882(1-2):85-8.
- [2] Arakawa A, et, al. Effects of clopidol on sporulation and infectivity of Eimeria tenella oocysts. Vet Parasitol. 1991 Jan;38(1):55-60.
- [3] Rodrigues T, et, al. Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3476-80.
Synonyms
