[CAS NO. 30315-93-6] Asymmetricdimethylarginine
PRODUCTS SPECIFICATIONS [30315-93-6]
DESCRIPTION [30315-93-6]
Overview
| MDL | MFCD00038406 |
|---|---|
| Molecular Weight | 202.25 |
| Molecular Formula | C8H18N4O2 |
| SMILES | CN(C)C(NCCC[C@H](N)C(O)=O)=N |
Summary
Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS) , and functions as a marker of endothelial dysfunction in a number of pathological states.
IC50 & Target
|
Human Endogenous Metabolite |
In Vitro
Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. Asymmetric dimethylarginine (ADMA) is elevated in HIV-1 infection [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT03377465 | Medical University of Lodz |
Embolic Stroke of Undetermined Source|Ischemic Stroke|Atrial Fibrillation and Flutter|Myocardial Infarction|Cardiac Tumor|Endocarditis|Patent Foramen Ovale
|
November 15, 2016 | Not Applicable |
| NCT04175093 | Assiut University |
Bronchial Asthma
|
November 29, 2019 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
H 2 O : 100 mg/mL ( 494.44 mM ; adjust pH to 2-3 with HCl)
DMSO : 100 mg/mL ( 494.44 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.9444 mL | 24.7219 mL | 49.4438 mL |
| 5 mM | 0.9889 mL | 4.9444 mL | 9.8888 mL |
| 10 mM | 0.4944 mL | 2.4722 mL | 4.9444 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (494.44 mM); Clear solution; Need ultrasonic
Synonyms
