[CAS NO. 30914-89-7] Flumexadol
PRODUCTS SPECIFICATIONS [30914-89-7]
DESCRIPTION [30914-89-7]
Overview
| MDL | MFCD00864259 |
|---|---|
| Molecular Weight | 231.21 |
| Molecular Formula | C11H12F3NO |
| SMILES | FC(C1=CC(C2CNCCO2)=CC=C1)(F)F |
Summary
IC50 & Target
|
5-HT 2C Receptor 25 nM (Ki) |
In Vivo
In rats and dogs dosed with 14 C-Flumexadol (CERM1841), the 14 C is excreted in the urine. The 14 C eliminated in the faeces of dog is significantly higher than for rat. Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species. Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances. The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid. In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate. The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 33.33 mg/mL ( 144.15 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.3251 mL | 21.6254 mL | 43.2507 mL |
| 5 mM | 0.8650 mL | 4.3251 mL | 8.6501 mL |
| 10 mM | 0.4325 mL | 2.1625 mL | 4.3251 mL |
References
- [1] Hache J, et al. The pharmacology of 1841 CERM, a new analgesic. Arzneimittelforschung. 1978;28(4):642-5.
- [2] Nilsson BM. 5-Hydroxytryptamine 2C (5-HT2C) receptor agonists as potential antiobesity agents. J Med Chem. 2006 Jul 13;49(14):4023-34.
- [3] Kucharczyk N, et al. Metabolites of 2-(3-trifluoromethylphenyl)tetrahydro-1,4-oxazine (CERM) 1841) in rats and dogs. Xenobiotica. 1979 Nov;9(11):703-11.
Synonyms
