[CAS NO. 34240-05-6] Adenosinedialdehyde
PRODUCTS SPECIFICATIONS [34240-05-6]
DESCRIPTION [34240-05-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 265.23 |
| Molecular Formula | C10H11N5O4 |
| SMILES | O=CC(OC(C=O)CO)N1C=NC2=C(N)N=CN=C12 |
Summary
In Vitro
Adenosine dialdehyde suppresses MNB cell replication in tissue culture with concentra tions of 1.5 μM with producing 50% inhibition [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals
[3]
.
Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice
[3]
.
Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Adult male A/J mice, weighing 20 to 25 g with MNB cells [3] |
| Dosage: | 1.5-2.5 mg/kg |
| Administration: | Subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval (minipump infusion) |
| Result: |
Significantly suppressed murine neuroblastoma tumor growth.
Prolongs the life span of tumor bearing mice. Did not suppress hematopoiesis when administered by steady state infusion [2] . |
Appearance
Oil
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 10 mg/mL ( 37.70 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7703 mL | 18.8516 mL | 37.7031 mL |
| 5 mM | 0.7541 mL | 3.7703 mL | 7.5406 mL |
| 10 mM | 0.3770 mL | 1.8852 mL | 3.7703 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.08 mg/mL (7.84 mM); Suspended solution; Need ultrasonic
References
- [1] V Ramakrishnan, et al. Adenosine dialdehyde and neplanocin A: Potent inhibitors of S-adenosylhomocysteine hydrolase in neuroblastoma N2a cells. Neurochem Int. 1987;10(4):423-31.
- [2] G V Madhavan, et al. Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem
- [3] B Bostrom, et al. Inhibitory effect of adenosine dialdehyde on in situ murine neuroblastoma growth.Cancer Res. 1988 Nov 1;48(21):5933-6.
