[CAS NO. 342795-08-8] Bragsin2
PRODUCTS SPECIFICATIONS [342795-08-8]
DESCRIPTION [342795-08-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 289.16 |
| Molecular Formula | C11H6F3NO5 |
| SMILES | O=C1C=C(C(F)(F)F)OC2=CC=C(OC)C([N+]([O-])=O)=C21 |
1 Publications Citing Use of MCE
Summary
Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC 50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells [1] .
IC50 & Target
IC50: 3 μM (BRAG2) [1]
In Vitro
Bragsin2 (50 μM) inhibits Arf GTPase activation in HeLa cells
[1]
.
Bragsin2 (50 μM) inhibits the growth of SUM149 and S68, with no effect on SUM159, which lacks adhesion molecules such as integrins and cadherins
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 345.83 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.4583 mL | 17.2915 mL | 34.5829 mL |
| 5 mM | 0.6917 mL | 3.4583 mL | 6.9166 mL |
| 10 mM | 0.3458 mL | 1.7291 mL | 3.4583 mL |
