[CAS NO. 343565-99-1] AG-7404

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PRODUCTS SPECIFICATIONS [343565-99-1]

Catalog

HY-19476

Brand

MCE

CAS

343565-99-1

DESCRIPTION [343565-99-1]

Overview

MDL	-
Molecular Weight	523.54
Molecular Formula	C26H29N5O7
SMILES	O=C(NCC1)[C@@H]1C[C@@H](/C=C/C(OCC)=O)NC([C@@H](N2C(C(NC(C3=NOC(C)=C3)=O)=CC=C2)=O)CC#C)=O

For research use only. We do not sell to patients.

Summary

AG-7404 is an inhibitor of picornaviral 3C protease , with anti-poliovirus activity ( EC ₅₀ =0.080-0.674 μM). AG-7404 has synergy with V-073 (HY-104074) or BTA798 (HY-106254), and fully inhibits all V-073-resistant variants ^[1] .

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Rhoden E,et al. Anti-poliovirus activity of protease inhibitor AG-7404, and assessment of in vitro activity in combination with antiviral capsid inhibitor compounds. Antiviral Res. 2013 May;98(2):186-91.