[CAS NO. 34839-70-8] Metiamide
PRODUCTS SPECIFICATIONS [34839-70-8]
DESCRIPTION [34839-70-8]
Overview
| MDL | MFCD00867517 |
|---|---|
| Molecular Weight | 244.38 |
| Molecular Formula | C9H16N4S2 |
| SMILES | S=C(NCCSCC1=C(C)N=CN1)NC |
Summary
Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.
IC50 & Target
Ki: 0.92 uM (H2 receptor)
In Vitro
Metiamide (SK&F 92058) is a competitive with aldehyde substrates and noncompetitive with the Human E3 Aldehyde Dehydrogenase coenzyme, binding to both the free E3 isozyme and the enzyme·coenzyme binary complex with K i values of 0.92 μM glycolaldehyde as the varied substrate [1] . Data is got as percentage change in GTPase activity induced by metiamide compared with the GTPase activity stimulated by HA (100 μM) [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 2.4 mg/mL ( 9.82 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.0920 mL | 20.4599 mL | 40.9199 mL |
| 5 mM | 0.8184 mL | 4.0920 mL | 8.1840 mL |
| 10 mM | --- | --- | --- |
References
- [1] Alexandra Kikonyogo ,Regina Pietruszko, Cimetidine and Other H2-Receptor Antagonists as Inhibitors of Human E3 Aldehyde Dehydrogenase. Molecular Pharmacology 1997; 52: 2267-271.
- [2] Hendrik Preuss, Prasanta Ghorai1, Anja Kraus, Constitutive Activity and Ligand Selectivity of Human, Guinea Pig, Rat, and Canine Histamine H2 Receptors. JPET 2007 vol. 321no. 3 983-995.
Synonyms
