[CAS NO. 35286-58-9] Ziyuglycoside I

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PRODUCTS SPECIFICATIONS [35286-58-9]

Catalog

HY-N0331

Brand

MCE

CAS

35286-58-9

DESCRIPTION [35286-58-9]

Overview

MDL	-
Molecular Weight	766.96
Molecular Formula	C41H66O13
SMILES	O[C@@H]1[C@@H](O)[C@]([H])(O[C@@H]2C(C)(C)[C@@](CC[C@]3(C)[C@]4([H])CC=C5[C@@]3(C)CC[C@]6(C(O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)=O)[C@@]5([H])[C@@](O)(C)[C@H](C)CC6)([H])[C@]4(C)CC2)OC[C@@H]1O

For research use only. We do not sell to patients.

Summary

Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics ^[1] . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53 , it can be a potential drug candidate for treating triple-negative breast cancer (TNBC) ^[2] .

In Vitro

Ziyuglycoside I (5-160 µM; 24 hours) reveals a marked anti-proliferation activity with an IC ₅₀ value of 13.96 µM in MDA-MB-231 cells ^[2] .
Ziyuglycoside I (5-20 µM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 µM ^[2] .
Ziyuglycoside I (5-20 µM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	5 µM, 10 µM, 20 µM, 40 µM, 80 µM, and 160 µM
Incubation Time:	24 hours
Result:	Showed cytotoxicity on MDA-MB-231 cells.

Cell Cycle Analysis ^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	5 µM, 10 µM, and 20 µM
Incubation Time:	24 hours
Result:	Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells

Western Blot Analysis ^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	5 µM, 10 µM, and 20 µM
Incubation Time:	24 hours
Result:	Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

Methanol : 125 mg/mL ( 162.98 mM ; Need ultrasonic)

DMSO : 100 mg/mL ( 130.38 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3038 mL	6.5192 mL	13.0385 mL
5 mM	0.2608 mL	1.3038 mL	2.6077 mL
10 mM	0.1304 mL	0.6519 mL	1.3038 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (2.71 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (2.71 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (2.71 mM); Clear solution

* All of the co-solvents are available by MCE.