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[CAS NO. 35286-58-9] Ziyuglycoside I
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N0331 |
| Brand: | MCE |
| CAS: | 35286-58-9 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 766.96 |
| Molecular Formula | C41H66O13 |
| SMILES | O[C@@H]1[C@@H](O)[C@]([H])(O[C@@H]2C(C)(C)[C@@](CC[C@]3(C)[C@]4([H])CC=C5[C@@]3(C)CC[C@]6(C(O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)=O)[C@@]5([H])[C@@](O)(C)[C@H](C)CC6)([H])[C@]4(C)CC2)OC[C@@H]1O |
Summary
Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics [1] . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53 , it can be a potential drug candidate for treating triple-negative breast cancer (TNBC) [2] .
In Vitro
Ziyuglycoside I (5-160 µM; 24 hours) reveals a marked anti-proliferation activity with an IC
50
value of 13.96 µM in MDA-MB-231 cells
[2]
.
Ziyuglycoside I (5-20 µM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 µM
[2]
.
Ziyuglycoside I (5-20 µM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 5 µM, 10 µM, 20 µM, 40 µM, 80 µM, and 160 µM |
| Incubation Time: | 24 hours |
| Result: | Showed cytotoxicity on MDA-MB-231 cells. |
Cell Cycle Analysis [1]
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 5 µM, 10 µM, and 20 µM |
| Incubation Time: | 24 hours |
| Result: | Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells |
Western Blot Analysis [1]
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 5 µM, 10 µM, and 20 µM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
Methanol : 125 mg/mL ( 162.98 mM ; Need ultrasonic)
DMSO : 100 mg/mL ( 130.38 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.3038 mL | 6.5192 mL | 13.0385 mL |
| 5 mM | 0.2608 mL | 1.3038 mL | 2.6077 mL |
| 10 mM | 0.1304 mL | 0.6519 mL | 1.3038 mL |
References
- [1] Kim YH, et al. Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient. Biosci Biotechnol Biochem. 2008 Feb;72(2):303-11. Epub 2008 Feb 7.
- [2] Zhu X, et al. Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis. Int J Mol Sci. 2016 Nov 22;17(11). pii: E1903
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