[CAS NO. 35457-80-8] Midecamycin
PRODUCTS SPECIFICATIONS [35457-80-8]
DESCRIPTION [35457-80-8]
Overview
| MDL | MFCD00865000 |
|---|---|
| Molecular Weight | 813.97 |
| Molecular Formula | C41H67NO15 |
| SMILES | O[C@H]1[C@](O[C@H](C)[C@@H](O[C@@](O[C@@H](C)[C@@H]2OC(CC)=O)([H])C[C@]2(O)C)[C@@H]1N(C)C)([H])O[C@@H]([C@H](C[C@H]([C@H](/C=C/C=C/C3)O)C)CC=O)[C@H]([C@](CC(O[C@@H]3C)=O)([H])OC(CC)=O)OC |
2 Publications Citing Use of MCE
Summary
Midecamycin, an acetoxy-substituted macrolide antibiotic , is tested against gram-positive and gram-negative bacteria.
IC50 & Target
|
Macrolide |
In Vitro
Midecamycin inhibits the majority of streptococci , staphylococci , and strains of Haemophilus and Listeria at concentrations of less than 3.1 μg/mL [1] . Midecamycin is a 16-membered macrolide. Midecamycin is a new macrolide antibiotic, which is produced by Streptomyces mycarofaciens [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Streptomyces mycarofaciens
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 36 mg/mL ( 44.23 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.2285 mL | 6.1427 mL | 12.2855 mL |
| 5 mM | 0.2457 mL | 1.2285 mL | 2.4571 mL |
| 10 mM | 0.1229 mL | 0.6143 mL | 1.2285 mL |
References
- [1] Neu HC. In vitro activity of midecamycin, a new macrolide antibiotic. Antimicrob Agents Chemother. 1983 Sep;24(3):443-4.
- [2] Cong L, et al. Cloning and characterization of genes encoded in dTDP-D-mycaminose biosynthetic pathway from amidecamycin-producing strain, Streptomyces mycarofaciens. Acta Biochim Biophys Sin (Shanghai). 2007 Mar;39(3):187-93.
Synonyms
