[CAS NO. 354815-90-0] MurA-IN-1
PRODUCTS SPECIFICATIONS [354815-90-0]
DESCRIPTION [354815-90-0]
Overview
| MDL | MFCD01593500 |
|---|---|
| Molecular Weight | 215.25 |
| Molecular Formula | C13H13NO2 |
| SMILES | O=C(C1NC2=C(C=CC=C2)C3C1CC=C3)O |
Summary
MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC 50 values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively [1] . (A family of human MAPK-specific protein tyrosine phosphatases)
IC50 & Target
IC50: 0.23 μM (PTP1B), 0.8 μM (PTPN5), 0.75 μM (PTPN7), 0.09 μM (PTPRR) [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 232.29 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.6458 mL | 23.2288 mL | 46.4576 mL |
| 5 mM | 0.9292 mL | 4.6458 mL | 9.2915 mL |
| 10 mM | 0.4646 mL | 2.3229 mL | 4.6458 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (9.66 mM); Clear solution
