[CAS NO. 355406-76-7] RIPGBM
PRODUCTS SPECIFICATIONS [355406-76-7]
DESCRIPTION [355406-76-7]
Overview
| MDL | MFCD05670032 |
|---|---|
| Molecular Weight | 428.45 |
| Molecular Formula | C26H21FN2O3 |
| SMILES | CC(N(C(C1=O)=C(NCC2=CC=CC=C2)C(C3=C1C=CC=C3)=O)CC4=CC=C(F)C=C4)=O |
Summary
RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC 50 of ≤500 nM [1] .
IC50 & Target
EC50: ≤500 nM (Apoptosis, in GBM CSCs) [1]
In Vitro
RIPGBM induces caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 33.33 mg/mL ( 77.79 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3340 mL | 11.6700 mL | 23.3399 mL |
| 5 mM | 0.4668 mL | 2.3340 mL | 4.6680 mL |
| 10 mM | 0.2334 mL | 1.1670 mL | 2.3340 mL |
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