[CAS NO. 35700-23-3] Carboprost
PRODUCTS SPECIFICATIONS [35700-23-3]
DESCRIPTION [35700-23-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 368.51 |
| Molecular Formula | C21H36O5 |
| SMILES | CCCCC[C@](C)(O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C/C=C\CCCC(O)=O |
Summary
Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester [1] [2] .
IC50 & Target
|
FP |
In Vivo
The methyl ester of Carboprost (15(S)-15-Methyl Prostaglandin F2α; 15M-PGF2 alpha, 12.5 mg/monkey) loweres serum progesterone to 12% of pretreatment values within 24 hours, however progesterone returnes to normal limits within 48 hours
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01869556 | Samuel Lunenfeld Research Institute, Mount Sinai Hospital |
Postpartum Hemorrhage
|
June 4, 2013 | Not Applicable |
| NCT05518812 | Northwestern University |
Fibroid Uterus|Gynecologic Disease|Leiomyoma, Uterine
|
July 12, 2022 | Early Phase 1 |
| NCT03390010 | Aljazeera Hospital|Cairo University |
Cesarean Section
|
December 28, 2017 | Phase 1 |
| NCT00989027 | Samuel Lunenfeld Research Institute, Mount Sinai Hospital |
Postpartum Hemorrhage
|
June 2007 | Not Applicable |
Appearance
Oil
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 271.36 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7136 mL | 13.5682 mL | 27.1363 mL |
| 5 mM | 0.5427 mL | 2.7136 mL | 5.4273 mL |
| 10 mM | 0.2714 mL | 1.3568 mL | 2.7136 mL |
References
Synonyms
