[CAS NO. 3689-50-7] Oxomemazine
PRODUCTS SPECIFICATIONS [3689-50-7]
DESCRIPTION [3689-50-7]
Overview
| MDL | MFCD00868197 |
|---|---|
| Molecular Weight | 330.44 |
| Molecular Formula | C18H22N2O2S |
| SMILES | CC(CN1C2=C(C=CC=C2)S(C3=CC=CC=C13)(=O)=O)CN(C)C |
Summary
Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine is a selective antagonist for muscarinic M1 receptor , displays about 20-fold difference in the affinity for high ( K i = 84 nM, M1 receptor) and low ( K i = 1.65 μM, M2 receptor) affinity sites [1] . Oxomemazine an antihistamine and anticholinergic agent used for the study of cough treatment [2] .
IC50 & Target
|
H 1 Receptor
|
mGluR 1 84 nM (Ki) |
mGluR2 1.65 μM (Ki) |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 302.63 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.0263 mL | 15.1313 mL | 30.2627 mL |
| 5 mM | 0.6053 mL | 3.0263 mL | 6.0525 mL |
| 10 mM | 0.3026 mL | 1.5131 mL | 3.0263 mL |
References
Synonyms
