[CAS NO. 3778-76-5] Todralazine hydrochloride

Name: Todralazine hydrochloride
Brand: Arctom Scientific
SKU: AS937623

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PRODUCTS SPECIFICATIONS [3778-76-5]

Distributor

Catalog

AS937623

Brand

Arctom Scientific

CAS

3778-76-5

DESCRIPTION [3778-76-5]

Overview

MDL	-
Molecular Weight	268.70
Molecular Formula	C11H13ClN4O2
SMILES	O=C(NNC1=NN=CC2=C1C=CC=C2)OCC.[H]Cl

For research use only. We do not sell to patients.

Summary

Todralazine hydrochloride (Ecarazine hydrochloride) is an anti-hypertensive agent, acts as a β ₂ AR blocker, with antioxidant and free radical scavenging activity ^[1] .

IC50 & Target

β ₂ AR ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 465.20 mM ; Need ultrasonic)

H ₂ O : 14.29 mg/mL ( 53.18 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7216 mL	18.6081 mL	37.2162 mL
5 mM	0.7443 mL	3.7216 mL	7.4432 mL
10 mM	0.3722 mL	1.8608 mL	3.7216 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.74 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.74 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.74 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Dimri M, et al. Todralazine protects zebrafish from lethal effects of ionizing radiation: role of hematopoietic cell expansion. Zebrafish. 2015 Feb;12(1):33-47.

Synonyms

Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, hydrochloride (1:1)

Carbazic acid, 3-(1-phthalazinyl)-, ethyl ester, monohydrochloride

Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, monohydrochloride

Binazine

Binazin

N-Carbethoxy-N′-phthalazinohydrazide hydrochloride

2-Carbethoxy-1-(1-phthalazinyl)hydrazine hydrochloride

N¹-Carboethoxy-N¹-hydrazinophthalazine

Apirachol

Apiracohl

Ecarazine hydrochloride

Ecarazine

Todralazine hydrochloride

N-Carbethoxy-N′-(1-phthalazino)hydrazine hydrochloride

Apredor

Illcut

CEPH

Atapren

Propat

Apride

BT 621