[CAS NO. 37860-51-8] Bis-Tos-PEG4

Name: Bis-Tos-PEG4
Brand: Arctom Scientific
SKU: AS044480

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PRODUCTS SPECIFICATIONS [37860-51-8]

Fulfillment

Catalog

AS044480

Brand

Arctom Scientific

CAS

37860-51-8

DESCRIPTION [37860-51-8]

Overview

MDL	MFCD00075239
Molecular Weight	502.60
Molecular Formula	C22H30O9S2
SMILES	O=S(C1=CC=C(C)C=C1)(OCCOCCOCCOCCOS(C2=CC=C(C)C=C2)(=O)=O)=O

For research use only. We do not sell to patients.

Summary

Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs ^[1] .

IC50 & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Viscous liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Synonyms

Ethanol, 2,2′-[oxybis(2,1-ethanediyloxy)]bis-, 1,1′-bis(4-methylbenzenesulfonate)

Ethanol, 2,2′-[oxybis(2,1-ethanediyloxy)]bis-, bis(4-methylbenzenesulfonate)

Tetraethylene glycol, di-p-toluenesulfonate

Tetraethylene glycol ditosylate

3,6,9-Trioxaundecane-1,11-diol ditosylate

Tetraethylene glycol bis(p-toluenesulfonate)

Tetraethylene glycol bis(4-toluenesulfonate)

Tetraethylene glycol bistosylate

1,11-Bis(tosyloxy)-3,6,9-trioxaundecane

Tetraethylene glycol di-p-tosylate

1,11-Bis(p-tolylsulfonyloxy)-3,6,9-trioxaundecane

α,ω-Di(p-toluenesulfonyl)tetraethylene glycol

2,2′-[Oxybis(2,1-ethanediyloxy)]bis[ethanol] bis(4-methylbenzenesulfonate)

2-[2-[2-[2-[[(4-Methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

Bis[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethyl] ether

Bis-1,11-(p-toluenesulfonyloxy)-3,6,9-trioxaundecane

1,11-Ditosyl-3,6,9-trioxaundecane

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)